Aureomycin-FDA Information About Prescribing, side effects & Uses
Chickens
Increased rate of weight gain and improved feed efficiency.Amount of 10 mg chloretracycline hydrochloride per 50 lbs of body weight. It is recommended that 1 pound of Aureomycin 100 Granular Type A Medicated Article be diluted with 3 pounds of one of the feed ingredients to form a 4 pound working premix. Use 2 pounds of the working premix to make a preblend (see Use directions) for a Type C feed containing 50 g Aureomycin chlortetracycline / ton of feed.
Control of infectious synovitis caused by Mycoplasma synoviae susceptible to chlortetracycline.
Feed continuously for 7 to 14 days.100-200
Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to chlortetracycline.
Feed continuously for 7 to 14 days.200-400
Reduction of mortality due to Escherichia coli infections susceptible to chlortetracycline. Feed for 5 days (Drugs.com).
Increased rate of weight gain and improved feed efficiency.Amount of 10 mg chloretracycline hydrochloride per 50 lbs of body weight. It is recommended that 1 pound of Aureomycin 100 Granular Type A Medicated Article be diluted with 3 pounds of one of the feed ingredients to form a 4 pound working premix. Use 2 pounds of the working premix to make a preblend (see Use directions) for a Type C feed containing 50 g Aureomycin chlortetracycline / ton of feed.
Control of infectious synovitis caused by Mycoplasma synoviae susceptible to chlortetracycline.
Feed continuously for 7 to 14 days.100-200
Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to chlortetracycline.
Feed continuously for 7 to 14 days.200-400
Reduction of mortality due to Escherichia coli infections susceptible to chlortetracycline. Feed for 5 days (Drugs.com).
Recommended Dosage For Chickens
DOSAGE FORM: Type A Medicated Article
ROUTE OF ADMINISTRATION: Oral - For use in Type C medicated chicken feeds.
RECOMMENDED DOSAGES:
CHICKENS
10-50 g/t
Broiler/fryer chickens:
For increased rate of weight gain and improved feed efficiency.
100-200 g/t
Control of infectious synovitis caused by Mycoplasmasynoviae susceptible to chlortetracycline. (Feed continuously for 7 to 14 days)
200-400 g/t
Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to chlortetracycline. (Feed continuously for 7 to 14 days)
WARNING: Zero-day withdrawal period.
500 g/t
Reduction of mortality due to Escherichiacoli infections susceptible to chlortetracycline. (Feed for 5 days)
WARNING: Withdraw 24 hours prior to slaughter (FDA, 2).
ROUTE OF ADMINISTRATION: Oral - For use in Type C medicated chicken feeds.
RECOMMENDED DOSAGES:
CHICKENS
10-50 g/t
Broiler/fryer chickens:
For increased rate of weight gain and improved feed efficiency.
100-200 g/t
Control of infectious synovitis caused by Mycoplasmasynoviae susceptible to chlortetracycline. (Feed continuously for 7 to 14 days)
200-400 g/t
Control of chronic respiratory disease (CRD) and air sac infection caused by Mycoplasma gallisepticum and Escherichia coli susceptible to chlortetracycline. (Feed continuously for 7 to 14 days)
WARNING: Zero-day withdrawal period.
500 g/t
Reduction of mortality due to Escherichiacoli infections susceptible to chlortetracycline. (Feed for 5 days)
WARNING: Withdraw 24 hours prior to slaughter (FDA, 2).
Human Food Safety
A. Safe Concentrations of Total Residues
Recently, the Center for Veterinary Medicine (CVM) revised the tolerances for tetracycline drugs (61 FR 67453). Based on an ADI (ADI) of 0.025 mg/kg of body weight (bw) per day, reserving 60% of the ADI for milk and eggs, unified tolerances of 2 ppm for muscle, 6 ppm for liver and 12 ppm for kidney and fat now are codified for total tetracycline residues (i.e., tetracycline, oxytetracycline and chlortetracycline). The ADI for milk and eggs is calculated as follows:
Using the above ADI, reserving 50% of the nontissue ADI for eggs, and applying the current consumption factors, the tolerance for total tetracyclines in eggs is calculated as follow:
While the toxicology data would support a tolerance as high as 4.5 ppm for eggs, we are unable to build a relationship between this tolerance value and the tolerances in the other edible tissues. A tolerance of 400 ppb is established for residues of chlortetracycline in the eggs of laying hens. This value is consistent with both the incurred residues seen in the eggs of treated hens and the tolerances in other tissues.
B. Studies to Establish a Withdrawal Time
Recently, the Center for Veterinary Medicine (CVM) revised the tolerances for tetracycline drugs (61 FR 67453). Based on an ADI (ADI) of 0.025 mg/kg of body weight (bw) per day, reserving 60% of the ADI for milk and eggs, unified tolerances of 2 ppm for muscle, 6 ppm for liver and 12 ppm for kidney and fat now are codified for total tetracycline residues (i.e., tetracycline, oxytetracycline and chlortetracycline). The ADI for milk and eggs is calculated as follows:
Using the above ADI, reserving 50% of the nontissue ADI for eggs, and applying the current consumption factors, the tolerance for total tetracyclines in eggs is calculated as follow:
While the toxicology data would support a tolerance as high as 4.5 ppm for eggs, we are unable to build a relationship between this tolerance value and the tolerances in the other edible tissues. A tolerance of 400 ppb is established for residues of chlortetracycline in the eggs of laying hens. This value is consistent with both the incurred residues seen in the eggs of treated hens and the tolerances in other tissues.
B. Studies to Establish a Withdrawal Time
- "Aurofac 100: Determination of Chlortetracycline Residues in Eggs from Hens Fed 300ppm Chlortetracycline for Seven Consecutive Days," PE Gingher, January 20, 1989.
Study Director: PE Gingher
Study Location:
American Cyanamid Company
Agricultural Research Division
Princeton, NJ 08540
Twenty Hubbard White Leghorn laying hens were treated with 300 ppm CTC in the diet for seven consecutive days. Ten birds served as untreated controls. Eggs were collected from the treated birds from 0 through 12 days withdrawal and assayed microbiologically for residues of CTC. Eggs from control birds were assayed for CTC on days 0 and 5 of the withdrawal period. Eggs were assayed in order of collection until residues at two consecutive withdrawal days were less than 0.05 ppm. The study results are summarized in Table 1.
Table 1: Mean residues (ppm) of CTC in whole eggs from laying hens treated with 300 ppm CTC in the feed for seven consecutive days (FDA, 2).
All About Eggs
Everything you need to know about eggs from hatching them to eating them and everything in between. Go to All About Eggs
Find Out Symptoms and Treatments for Respiratory Diseases in Chickens
References:
- Aureomycin-FDA prescribing information, side effects, and uses. Retrieved June 1, 2017 from Drugs.com https://www.drugs.com/pro/aureomycin.html
- NADA 048-761 Aureomycin; Type A Medicated Article - supplemental approval (July 31, 1998). FOIA Drug Summaries. https://www.fda.gov/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm064719.htm
